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DNA Damage/DNA Repair
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Stem Cells & Wnt
- GSK-3
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Hippo
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Ubiquitin
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NF-κB
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GPCR & G Protein
- Ras
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- MT Receptor
- PAFR
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- cAMP
- CXCR
- CaSR
- TAAR
- Glucagon Receptor
- LTR
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- CCK receptor
- Leukotriene
- FPR
- GRK
- Prostaglandin Receptor
- PKD
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- Neurokinin Receptor
- GNRH Receptor
- PKG
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- Angiotensin Receptor
- Bradykinin Receptor
- Imidazoline Receptor
- Bombesin Receptor
- RGS
- Neurotensin Receptor
- Sigma Receptor
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- PAR
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- NPY receptor
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- DOCK
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- GPCR19
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Endocrinology & Hormones
- Adrenergic Receptor
- 5-alpha Reductase
- Estrogen/progestogen Receptor
- Androgen Receptor
- RAAS
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- GPR
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- THR
- ACE
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- TSH Receptor
- GNRH Receptor
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Transmembrane Transporters
- CD markers
- Calcium Channel
- Sodium Channel
- ATPase
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- Potassium Channel
- GluR
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- P-gp
- Proton Pump
- CFTR
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- SGLT
- OCT
- CRM1
- GLUT
- GlyT
- NMDAR
- VDAC
- MTP
- VMAT
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- Amino acid transporter
- Mechanosensitive Channel
- OAT
- NKCC
- BCRP
- NCX
- OATP
- TRP Channel
- VRAC
- Aquaporin
- EAAT
Metabolism
- PPAR
- P450 (e.g. CYP17)
- HSP (HSP90)
- PDE
- Hydroxylase
- Factor Xa
- DHFR
- Aminopeptidase
- Dehydrogenase
- Procollagen C Proteinase
- Phospholipase (e.g. PLA)
- DPP
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- Phosphorylase
- Liver X Receptor
- FAAH
- Acyltransferase
- Fatty Acid Synthase
- NAMPT
- LDL
- Casein Kinase
- Decarboxylase
- Retinoid Receptor
- Thioredoxin
- FXR
- Transferase
- Serine/threonin kinase
- CETP
- IDO/TDO
- phosphatase
- GLUT
- HMG-CoA Reductase
- Vitamin
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- Lipoxygenase
- FOX
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- Catalase
- THR
- ACSS2
- ROR
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- ACE
- Thioredoxin Reductase
- PDHK
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- Xanthine Oxidase
- Mannosidase
- PGC-1α
- Adenosine Deaminase
- Aldose Reductase
- CPSase
- Leukotriene
- Adenosine Kinase
- OXPHOS
- Glutathione
- Acetyl-CoA carboxylase
- Mitochondrial Metabolism
- Peroxidases
- SHIP
- PCSK9
- Mitochondrial pyruvate carrier
- PREP
- PGDS
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- Neprilysin
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- LDH
- Carbohydrate Metabolism
- CAR
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- γGCS
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- ATP-citrate lyase
- FAO
- FTase
- SOD
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- GTPCH
- SGK
- GOT
- Serine hydrolase
- Epoxide Hydrolase
- glucocerebrosidase
- FABP
Proteases
- HDAC
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- Caspase
- Aminopeptidase
- HCV Protease
- DPP
- HIV Protease
- MMP
- Thrombin
- Acyltransferase
- Cysteine Protease
- MALT
- Glutaminase
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- Serine Protease
- Neprilysin
- SGK
- PREP
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- 3C-Like Protease
- PAD
- PCSK9
- Secretase
- Cathepsin B
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Microbiology
- HCV Protease
- Integrase
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- HIV Protease
- Anti-infection
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- Neuraminidase
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Others
- ADC Cytotoxin
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- Antineoplastic and Immunosuppressive Antibiotics
- Selection Antibiotics for Transfected Cell
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- Antibiotics for Plant Cell Culture
- Hydrotropic Agents
- Dyes
- PROTAC
- PROTAC Linker
- E3 ligase Ligand
- Target Protein Ligand
- Others
- Antibody-Drug Conjugate

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GSK-3 Inhibitors: A Double-Edged Sword? - An Update on Tideglusib

by Selleckchem | May 05 2020

GSK-3 inhibitors are an emerging tool for clinical interventions in human diseases and represent a niche area in combinational therapy. They possess diverse facets in applications of nervous system disorders, Type 2 diabetes, regenerative medicine and cancer. However, conflicting reports suggest the controversial role of GSK-3 inhibitors in cancers. This review aims to highlight the rise of GSK-3 inhibitors as tools for molecular-targeted research and its shift to a promising drug candidate. The review also focuses on key GSK-3 inhibitors and their roles in cancer and regenerative medicine with special emphasis to tideglusib. In addition, the decisive roles of GSK-3 in various molecular pathways will be concisely reviewed. Finally, this review concludes the emergence of GSK-3 inhibitors as a 'double-edged sword' in the treatment against human diseases cautioning researchers about the potential ramifications of off-target pharmacological effects.

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Cat.No.	Product Name	Information
S2823	Tideglusib	Tideglusib is an irreversible, non ATP-competitive GSK-3β inhibitor with IC50 of 60 nM in a cell-free assay; fails to inhibit kinases with a Cys homologous to Cys-199 located in the active site. Phase 2.

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